Anne Baudry Responses to Antidepressants MiR - 16 Targets the Serotonin Transporter : A New Facet for Adaptive
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, 1537 (2010); 329 Science et al. Anne Baudry Responses to Antidepressants MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): May 13, 2014 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/329/5998/1537.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2010/09/15/329.5998.1537.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/329/5998/1537.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/329/5998/1537.full.html#ref-list-1 , 5 of which can be accessed free: cites 20 articles This article http://www.sciencemag.org/content/329/5998/1537.full.html#related-urls 6 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/neuroscience Neuroscience subject collections: This article appears in the following
منابع مشابه
miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants.
The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological target of selective serotonin reuptake inhibitor (SSRI) antidepressants. We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression. In mice, chronic trea...
متن کاملAnne Baudry , Facet for Adaptive Responses to Antidepressants MiR - 16 Targets the Serotonin Transporter : A New
. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of October 1, 2010 ): The following resources related to this article are available online at www...
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In the clinic selective serotonin reuptake inhibitors (SSRIs), like Fluoxetine, remain the primary treatment for major depression. It has been suggested that miR-16 regulates serotonin transporters (SERT) via raphe nuclei and hippocampal responses to antidepressants. However, the underlying mechanism and regulatory pathways are still obtuse. Here, a chronic unpredicted mild stress (CUMS) depres...
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The serotonin transporter (SERT) is a key regulatory molecule in serotonergic transmission implicated in numerous biological processes relevant to human disorders. Recently, it was shown that SERT expression is controlled by miR-16 in mouse brain. Here, we show that SERT expression is regulated additionally by miR-15a as well as miR-16 in human and rat tissues. This post-transcriptional regulat...
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